![New 'highly virulent' HIV strain discovered in the Netherlands](https://www.portugalcolonial.pt/media/shared/articles/0c/cf/90/New--highly-virulent--HIV-strain-di-313636.jpg)
-
Sabalenka dedicates US Open to family 'who never gave up' on dream
-
Venezuela takes diplomatic jab at Brazil in spat over election
-
Multiple people shot along highway in US state of Kentucky
-
In Papua New Guinea, Pope holds mass 'at the edge of the world'
-
Hewett stays positive for wheelchair tennis despite agonising defeat
-
Three things on US Open champion Aryna Sabalenka
-
Sabalenka downs Pegula to win US Open thriller
-
USA slump to first home defeat against Canada in 67 years
-
Argentina hand Australia record 67-27 loss in Rugby Championship
-
England impress on Carsley bow, Germany, Dutch hit five
-
AFP photographer wins top prize for Gaza coverage
-
No Love for Packers for three weeks after ligament sprain: reports
-
Pedro Almodovar: chronicler of modern Spain crowned in Venice
-
Trump sounds dark tone at rally, Harris 'ready' for debate
-
Wirtz and Musiala dazzle to kick-start new Germany era
-
Chinese teenager takes 7th gold of Paris Paralympics
-
England interim boss Carsley 'respects' divided opinions over anthem
-
Neuville moves to the front in the Acropolis Rally
-
Garfield, Pugh charm Toronto in new romance 'We Live in Time'
-
21 boys confirmed dead in Kenya school inferno
-
Over 100,000 protest in France against new prime minister
-
Golden 30 minutes takes China to swimming Paralympics swimming domination
-
Green leads Australia to T20 series sweep of Scotland
-
Nigeria, Cameroon win afer chaotic AFCON build-ups
-
Nicole Kidman: A-lister, cinematic chameleon, wins in Venice
-
'I had to prove myself', says Kolisi after win against All Blacks
-
Almodovar wins top prize at Venice film festival
-
Grealish savours England redemption after 'worst summer'
-
Carsley makes flying start as England interim boss in win over Ireland
-
Springboks close on Rugby Championship with storming win over All Blacks
-
Sri Lanka's De Silva and Kamindu Mendis defy England in third Test
-
Farrell's Racing lose on opening day of Top 14
-
Dunbar takes second Vuelta stage as Roglic closes in on victory
-
Fritz eyes US Open glory to end 21 years of American hurt
-
Thousands protest in France against new prime minister
-
Trump to hold rally in swing state, Harris preps for debate
-
Stone at the double as Sri Lanka collapse against England in third Test
-
French tennis player takes legal action over online abuse
-
Italy backs Kyiv's 'legitimate defence' as Zelensky presses allies
-
The Body Shop rescued from administration after deal
-
Smoke and screams: The horror of Kenya's school dorm inferno
-
MotoGP leader Martin roars to victory in San Marino sprint
-
Ireland and UK to 'reset' relations as Starmer begins Dublin visit
-
Ma Lin turns brutal encounter with bear into glorious Paralympic career
-
Flintoff appointed England Lions head coach
-
Sri Lanka hit back as Pope falls during England collapse in second Test
-
Kyiv hits Russian ammo depot as Moscow advances in east
-
Italy PM states 'determined' support as Zelensky presses allies
-
Bagnaia claims pole for San Marino MotoGP with lap record
-
Meet the Woodhalls: Track and field couple light up Paralympics and Olympics
![New 'highly virulent' HIV strain discovered in the Netherlands](https://www.portugalcolonial.pt/media/shared/articles/0c/cf/90/New--highly-virulent--HIV-strain-di-313636.jpg)
New 'highly virulent' HIV strain discovered in the Netherlands
Oxford researchers announced Thursday the discovery of a highly virulent strain of HIV that has been lurking in the Netherlands for decades, but because of the effectiveness of modern treatments, is "no cause for alarm."
Their analysis, published Thursday in the journal "Science," showed that patients infected with what they call the "VB variant" had 3.5 to 5.5 times higher levels of the virus in their blood than those infected with other variants, as well as a more rapidly fading immune system.
However, the study also found that after starting treatment, individuals with the VB variant had similar immune system recovery and survival to individuals with other HIV variants.
"There's no cause for alarm with this new viral variant," said Oxford epidemiologist Chris Wymant, the lead author on the paper, in an interview with AFP.
The variant likely arose in the late 1980s and early 1990s in the Netherlands, according to the researchers, but began to decline around 2010.
Since modern interventions still seem to work on the variant, the research team believes that widespread HIV treatment in the Netherlands did not contribute to the virus's evolution, and that early detection and treatment are paramount.
"Our findings emphasize the importance of World Health Organization guidance that individuals at risk of acquiring HIV have access to regular testing to allow early diagnosis, followed by immediate treatment," said co-author Christophe Fraser, also an Oxford researcher, in a press release announcing the findings.
The work also supports the theory that viruses can evolve to become more virulent, a widely-hypothesized idea for which few real-world examples have been found.
The Delta variant of the novel coronavirus was another recent example.
The discovery of the HIV variant should therefore "be a warning that we should never be overconfident about saying viruses will just evolve to become milder," said Wymant to AFP.
In total, the team found 109 people infected with the VB variant, with only four living outside the Netherlands, but still in western Europe.
- 500 mutations -
The HIV virus is constantly evolving, so much so that each person infected has a slightly different version.
The VB variant, however, was found to have over 500 mutations.
"Finding a new variant is normal, but finding a new variant with unusual properties is not -- especially one with increased virulence," Wyman explained.
The research team first identified the VB variant in 17 HIV positive individuals by parsing a broad data set from the BEEHIVE project, a data collection and analysis initiative in Europe and Uganda.
Because 15 of the 17 were from the Netherlands, they further studied data from 6,700 HIV-positive Dutch individuals, identifying 92 others.
The earliest appearance of the VB variant in their data was found in someone diagnosed in 1992 who had an early version of the variant, and the most recent in 2014.
Other researchers have since found other individuals with the variant diagnosed after 2014.
Doctors usually measure HIV's deterioration of the immune system by monitoring the decline of CD4 T-cells, which are targeted by the HIV virus and pivotal for protecting the body against infections.
In patients infected with the VB variant, CD4 decline occurred twice as fast compared to other variants, "placing them at risk of developing AIDS much more rapidly," the researchers said.
In addition to its increased impact on the immune system, the team also found the VB variant to be more highly transmissible.
They came to that conclusion after comparing the different versions of the VB variant drawn from infected patients.
The fact that they were so similar suggests that the virus passed rapidly to someone else before it could accumulate many mutations.
- 'Critical' to diagnose and treat early -
"Because the VB variant causes a more rapid decline in immune system strength, this makes it critical that individuals are diagnosed early and start treatment as soon as possible," the press statement noted.
"This limits the amount of time HIV can damage an individual's immune system and jeopardize their health," added Fraser.
Fraser is also the principal investigator of the BEEHIVE project, which was launched in 2014 to gather data on how mutations in the HIV virus can lead to varying degrees of severity among patients.
Those differences have previously been thought to mostly relate to the strength of individuals' own immune systems.
The researchers said they could not identify which genetic mutation in the VB variant caused its virulence, but they hope future studies will be able to.
F.Moura--PC